Research
Below is a list of research done on black raspberries. They are sorted under very general categories with the link titles giving a description of the research focus.
General Scientific Black Raspberry Publications:
- Foodstuffs for preventing cancer: the preclinical and clinical development of berries.
- Anthocyanins and their role in cancer prevention.
- Laboratory and clinical studies of cancer chemoprevention by antioxidants in berries.
- Bioactive food components and cancer risk reduction.
- Cancer prevention with freeze-dried berries and berry components.
- Molecular mechanisms involved in chemoprevention of black raspberry extracts: from transcription factors to their target genes.
- Pharmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries daily for 7 days.
- Black raspberry extract and fractions contain angiogenesis inhibitors.
- Inhibition of cellular transformation by berry extracts.
- Perspectives in cancer chemoprevention.
- Cancer chemoprevention: principles and prospects.
Black raspberry and the lower GI tract:
- Effect of black raspberry ( Rubus occidentalis L.) extract variation conditioned by cultivar, production site, and fruit maturity stage on colon cancer cell proliferation.
- Modulation of genetic and epigenetic biomarkers of colorectal cancer in humans by black raspberries: a phase I pilot study.
- Anti-inflammatory effects of freeze-dried black raspberry powder in ulcerative colitis.
- Black raspberries inhibit intestinal tumorigenesis in apc1638+/- and Muc2-/- mouse models of colorectal cancer.
- Intestinal epithelial cell accumulation of the cancer preventive polyphenol ellagic acid–extensive binding to protein and DNA.
Black raspberry and the upper GI tract:
- Effects of human oral mucosal tissue, saliva, and oral microflora on intraoral metabolism and bioactivation of black raspberry anthocyanins.
- Black raspberry components inhibit proliferation, induce apoptosis, and modulate gene expression in rat esophageal epithelial cells.
- Formulation and in vitro-in vivo evaluation of black raspberry extract-loaded PLGA/PLA injectable millicylindrical implants for sustained delivery of chemopreventive anthocyanins.
- A rapid and sensitive LC-MS/MS method for quantification of four anthocyanins and its application in a clinical pharmacology study of a bioadhesive black raspberry gel.
- Distribution of anthocyanins delivered from a bioadhesive black raspberry gel following topical intraoral application in normal healthy volunteers.
- Topical application of a bioadhesive black raspberry gel modulates gene expression and reduces cyclooxygenase 2 protein in human premalignant oral lesions.
- Effects of a topically applied bioadhesive berry gel on loss of heterozygosity indices in premalignant oral lesions.
- Prevention and therapy of squamous cell carcinoma of the rodent esophagus using freeze-dried black raspberries.
- Transitioning from preclinical to clinical chemopreventive assessments of lyophilized black raspberries: interim results show berries modulate markers of oxidative stress in Barrett’s esophagus patients.
- Suppression of the tumorigenic phenotype in human oral squamous cell carcinoma cells by an ethanol extract derived from freeze-dried black raspberries.
- Modulation of N-nitrosomethylbenzylamine metabolism by black raspberries in the esophagus and liver of Fischer 344 rats.
- Black raspberries inhibit N-nitrosomethylbenzylamine (NMBA)-induced angiogenesis in rat esophagus parallel to the suppression of COX-2 and iNOS.
- Inhibition of the growth of premalignant and malignant human oral cell lines by extracts and components of black raspberries.
- Chemoprevention of oral cancer by black raspberries.
- Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries.
- Inhibition of N-nitrosobenzylmethylamine metabolism and DNA binding in cultured rat esophagus by ellagic acid.
Other black raspberry studies:
- A black raspberry extract inhibits proliferation and regulates apoptosis in cervical cancer cells.
- Topical treatment with black raspberry extract reduces cutaneous UVB-induced carcinogenesis and inflammation.
- Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress.
- Urinary excretion of black raspberry (Rubus occidentalis) anthocyanins and their metabolites.
- Black raspberry extracts inhibit benzo(a)pyrene diol-epoxide-induced activator protein 1 activation and VEGF transcription by targeting the phosphotidylinositol 3-kinase/Akt pathway.
- Inhibition of benzo(a)pyrene diol-epoxide-induced transactivation of activated protein 1 and nuclear factor kappaB by black raspberry extracts.
- Interactive gene expression pattern in prostate cancer cells exposed to phenolic antioxidants.
Black raspberry characterization:
- Modeling relationships among active components in black raspberry (Rubus occidentalis L.) fruit extracts using high-resolution (1)H nuclear magnetic resonance (NMR) spectroscopy and multivariate statistical analysis.
- Processing and storage effects on monomeric anthocyanins, percent polymeric color, and antioxidant capacity of processed black raspberry products.
- Cyanidin 3-rutinoside and cyanidin 3-xylosylrutinoside as primary phenolic antioxidants in black raspberry.
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